Category: MRI

MR Imaging in Ataxias Consensus Recommendations by the Ataxia Global Initiative Working Group on MRI Biomarkers

As members of the Ataxia Global Initiative (AGI) MR Biomarkers Study Group that authored the paper Kirsi Kinnunen and Niccolo Fuin hope that these guidelines on harmonizing MRI data acquisition will be helpful for ataxia study sponsors.

Validation of IXIQ.Ai+gBSI : an automated framework for caudate atrophy measurement in Huntington’s disease

We have developed a fully automated framework that uses deep learning for caudate segmentation (IXIQ. Ai) and generalised BSI (gBSI) for longitudinal measurements. Here, we validate the new method by comparing its volumetric scores with those of the standard manual pipeline (Man+BSI). Man+BSI produced larger caudate volumes than IXIQ.

Deep-learning methods for enrichment of Alzheimer’s Disease clinical trials using MRI and PET

  Drug development trials aimed to halt Alzheimer’s disease (AD) progression favour recruitment of participants at early stages, preferably before symptomatic onset. In this investigation, we developed a deep-learning framework to differentiate participants with accelerated cognitive decline from those that remain cognitively stable within 24 months.