Here we train an AI method to segment the hippocampus into subfields (CA1-3 CA4+DG, and Subiculum) from standard resolution T1W MRI alone to assess utility as biomarkers compared to whole hippocampal volume, in the absence of a high-resolution T2 MRI.
Drug development trials aimed to halt Alzheimer’s disease (AD) progression favour recruitment of participants at early stages, preferably before symptomatic onset. In this investigation, we developed a deep-learning framework to differentiate participants with accelerated cognitive decline from those that remain cognitively stable within 24 months.