Category: Alzheimers Disease

Fully automatic deep-learning based segmentation of hippocampal subfields from standard resolution T1W MRI in Alzheimer’s disease

Here we train an AI method to segment the hippocampus into subfields (CA1-3 CA4+DG, and Subiculum) from standard resolution T1W MRI alone to assess utility as biomarkers compared to whole hippocampal volume, in the absence of a high-resolution T2 MRI.

Deep-learning methods for enrichment of Alzheimer’s Disease clinical trials using MRI and PET

  Drug development trials aimed to halt Alzheimer’s disease (AD) progression favour recruitment of participants at early stages, preferably before symptomatic onset. In this investigation, we developed a deep-learning framework to differentiate participants with accelerated cognitive decline from those that remain cognitively stable within 24 months.