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Alzheimer’s Association International Conference - AAIC

AAIC 2020 will bring together international investigators, clinicians and care researchers to discuss the latest studies, theories and discoveries that will help bring the world closer to breakthroughs in dementia science.

Medical Image Understanding and Analysis - MIUA

MIUA is a UK-based international conference for the communication of image processing and analysis research and its application to medical imaging and biomedicine. This is a rapidly growing subject with ever increasing real-world applicability.
MIUA welcomes all researchers in medical imaging including mathematicians, computer scientists, bioinformaticians, clinicians, engineers and bioscientists.

MIUA is the principal UK forum for communicating research progress within the community interested in image analysis applied to medicine and related biological science. The meeting is designed for the dissemination and discussion of research in medical image understanding and analysis, and aims to encourage the growth and raise the profile of this multi-disciplinary field by bringing together the various communities including among others:

Webinar: Optimization of Tau PET Imaging for Alzheimer’s Clinical Development

In recent years, there has been an increasing focus on investigating the role of Tau in the onset and progression of Alzheimer’s Disease (AD), and in other neurodegenerative diseases associated with the accumulation of pathological misfolded Tau, such as progressive supranuclear palsy (PSP) and frontotemporal lobar degeneration (FTLD). Studies using recently introduced second-generation Tau tracers suggests that these tracers are binding to Tau with higher specificity compared to previous tracers, leading to increased interest in Tau within clinical studies. However, it’s still unclear what role Tau imaging will play in clinical trials: should Tau be used as a clinical endpoint; and how does it link to other biomarkers such as amyloid-beta, with some studies suggesting that amyloid-beta triggers the spread of Tau beyond the MTL region.

Given that the majority of Tau studies have been conducted using first-generation PET tracers, which had shown high incidences of off-site binding, it will be important to review the current data to understand what we know about Tau in AD and how second-generation tracers are being applied in clinical studies. Additionally, this webinar will cover the steps being taken to advance Tau PET operational and analytical methodologies in AD clinical studies and other Tau-related neurodegenerative diseases.

- Victor L. Villemagne, Associate Professor, Department of Medicine, Department of Molecular Imaging and Therapy, Centre for PET, Austin Health, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne
- Richard Manber, Biomarker Scientist, IXICO

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