Understanding Alzheimer’s Disease (AD) requires more than just a focus on amyloid and tau. This webinar explores how radiology is uncovering the impact of comorbidities—such as neuroinflammation and cerebrovascular pathology—on AD risk and progression.

Join Frederik Barkhof and Alex Henderson as they discuss the evolving role of imaging in clinical trials, emerging therapeutic targets, and the operational realities of implementing advanced imaging strategies.

What You’ll Learn:

• Comorbidities in AD Progression
  Explore how neuroinflammation and vascular pathology interact with core AD mechanisms.
• Imaging in Clinical Trials
  Learn how MRI, PET, and quantitative methods are used to identify and monitor biomarkers over time.
• Emerging Therapeutic Targets
  Discover new directions in AD treatment beyond amyloid and tau, including APOE4 and targeted brain delivery.
• Radiology in Practice
  Hear how imaging protocols are being adapted and standardized to support trial success and cross-site consistency.
• Collaboration & Infrastructure
  Understand the importance of cross-disciplinary teamwork and investment in imaging infrastructure.

About the speakers and moderator

Frederik Barkhof - Professor of Neuroradiology, Amsterdam UMC and UCL

Frederik Barkhof is Professor of Neuroradiology at Amsterdam UMC (NL) and at UCL in London (UK). His research interests focus on multiple sclerosis (spinal cord MRI, grey matter, atrophy), ageing (white matter lesions, microbleeds) and dementia (structural, functional, molecular MR and PET). He has (co)authored >1000 papers referenced in PubMed and is listed among 3000 most influential scientists world-wide by Thompson-Reuters. He is the author of the books “Neuroimaging in Dementia” and “Clinical Neuroradiology: the ESNR textbook” of the normal human brain and on movement disorders. He has contributed to the understanding of the functional anatomy of the basal ganglia using fMRI and the diffusion tensor.

Alexandra Henderson, Radiology Manager - IXICO
Alexandra Henderson, MSc, is Radiology Manager at IXICO. She holds an MSc in Clinical Neuroscience from University College London and a BSc in Biomedical Sciences from Northumbria University.

At IXICO, Alex manages the radiology operations in clinical trials, including Alzheimer’s disease, focusing on PET and MRI read form and paradigm development, operational reader management, and reporting quality. Her work bridges operations and radiology, supporting the integration of image interpretation into clinical trial workflows.

Moderator: Kirsi Kinnunen, Principal Biomarker Scientist – IXICO
Kirsi is a Senior Clinical Neuroscientist (PhD) and Chartered Psychologist with 15+ years of clinical neuroscience research experience. She focuses on brain imaging in CNS clinical trials, with expertise in Alzheimer's, Parkinsonian syndromes, Huntington's, multiple sclerosis, spinocerebellar ataxia, and traumatic brain injury. Kirsi provides science input and imaging planning help for biotechs during the development and maintenance stages of clinical trials.


This webinar concluded October 22^nd 2025

 

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