As members of the Ataxia Global Initiative (AGI) MR Biomarkers Study Group that authored the paper Kirsi Kinnunen and Niccolo Fuin hope that these guidelines on harmonizing MRI data acquisition will be helpful for ataxia study sponsors.

In the paper, we provide recommendations for both a basic structural MRI protocol and an advanced multi-modal MRI protocol (structural MRI, MRS, dMRI, QSM, rs-MRI), including acceptable ranges of acquisition parameters for adequate data quality. We additionally discuss outcome measures relevant for ataxias, based on use cases from available literature.

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