# Validation of IXIQ.Ai+gBSI : an automated framework for caudate atrophy measurement in Huntington’s disease 4 May 23 publications # Validation of IXIQ.Ai+gBSI : an automated framework for caudate atrophy measurement in Huntington’s disease Dorian Pustina Emily Gantman Marina Papoutsi Rachael Scahill Robin Wolz MRI Huntingtons Disease IXIQ.Ai [ ](https://x.com/intent/tweet?url=https://ixico.com/news-and-resources/publications/validation-of-ixiq-ai-gbsi-an-automated-framework-for-caudate-atrophy-measurement-in-huntingtons-disease/) [ ](https://bsky.app/intent/compose?text=https://ixico.com/news-and-resources/publications/validation-of-ixiq-ai-gbsi-an-automated-framework-for-caudate-atrophy-measurement-in-huntingtons-disease/) [ ](https://www.facebook.com/sharer/sharer.php?u=https://ixico.com/news-and-resources/publications/validation-of-ixiq-ai-gbsi-an-automated-framework-for-caudate-atrophy-measurement-in-huntingtons-disease/) [ ](https://www.linkedin.com/shareArticle?mini=true&url=https://ixico.com/news-and-resources/publications/validation-of-ixiq-ai-gbsi-an-automated-framework-for-caudate-atrophy-measurement-in-huntingtons-disease/) [ Download ](/assets/downloads/Validation-of-IXIQ.Ai+gBSI-an-automated-framework-for-caudate-atrophy-measurement-in-Huntingtons-disease-HDTC-2023-Poster.pdf) ![Validation ofIXIQ.Ai+gBSI an automated framework for caudate atrophy measurement in Huntingtons disease landing page image](/assets/blog-images/Validation-ofIXIQ__ScaleMaxWidthWzgwMF0_FillMaxWzgwMCw0NTBd_ExtRewriteWyJqcGciLCJ3ZWJwIl0.Ai+gBSI-an-automated-framework-for-caudate-atrophy-measurement-in-Huntingtons-disease-landing-page-image.webp)We have developed a fully automated framework that uses deep learning for caudate segmentation (IXIQ.Ai) and generalised BSI (gBSI) for longitudinal measurements. Here, we validate the new method by comparing its volumetric scores with those of the standard manual pipeline (Man+BSI). Man+BSI produced larger caudate volumes than IXIQ.Ai+gBSI at baseline, but there was no significant difference in annualized volume change. In addition, both methods showed significant differences in baseline volume and longitudinal change between symptomatic and non-symptomatic HD gene-carriers and controls, with comparable effect sizes. The IXIQ.Ai+gBSI method therefore produces volume estimates that are equally sensitive to disease progression as the Man+BSI, but in a faster, automated fashion. [ Back to Scientific Publications ](/news-and-resources/publications/) ### Recents ![Evaluating the Impact of Scanner Harmonisation with ComBat on Longitudinal Brain Volume Measures in Huntington’s Disease](/assets/blog-images/EHDN-2026-Poster__ScaleMaxWidthWzgwMF0_FillMaxWzgwMCw0NTBd_ExtRewriteWyJwbmciLCJ3ZWJwIl0.webp) 29 Oct 26 publications [Evaluating the Impact of Scanner Harmonisation with ComBat on Longitudinal Brain Volume Measures in Huntington’s Disease](/news-and-resources/publications/new-blog-evaluating-the-impact-of-scanner-harmonisation-with-combat-on-longitudinal-brain-volume-measures-in-huntingtons-disease-post/) [Neuromelanin-Sensitive MRI of the Substantia Nigra: Comparing TSE and MT-GRE Contrast](/news-and-resources/publications/contrast-ratio-assessment-of-the-substantia-nigra-in-neuromelanin-sensitive-mri/) [Improving Neuromelanin-sensitive MRI measurement ](/news-and-resources/publications/improving-neuromelanin-sensitive-mri-measurement/) [Further validation of IXI technology platform automation capabilities](/news-and-resources/publications/further-validation-of-ixi-technology-platform-automation-capabilities/) [Interchangeability of blood-based biomarkers and PET to identify Alzheimer's disease pathology](/news-and-resources/publications/interchangeability-of-blood-based-biomarkers-and-pet-to-identify-alzheimers-disease-pathology/) ### Library [November 2026](/news-and-resources/publications/archive/2026/11/) [October 2026](/news-and-resources/publications/archive/2026/10/) [September 2026](/news-and-resources/publications/archive/2026/09/) [July 2026](/news-and-resources/publications/archive/2026/07/) [June 2026](/news-and-resources/publications/archive/2026/06/) [May 2026](/news-and-resources/publications/archive/2026/05/) [April 2026](/news-and-resources/publications/archive/2026/04/) [March 2026](/news-and-resources/publications/archive/2026/03/) [February 2026](/news-and-resources/publications/archive/2026/02/) [January 2026](/news-and-resources/publications/archive/2026/01/) [2025](/news-and-resources/publications/archive/2025/) [2024](/news-and-resources/publications/archive/2024/) [2023](/news-and-resources/publications/archive/2023/) [2022](/news-and-resources/publications/archive/2022/) [2021](/news-and-resources/publications/archive/2021/) [2020](/news-and-resources/publications/archive/2020/) [2019](/news-and-resources/publications/archive/2019/)