# Validation of a Jacobian AI-based method to measure cerebellar volume changes in multiple system atrophy 3 Apr 23 publications # Validation of a Jacobian AI-based method to measure cerebellar volume changes in multiple system atrophy Bianca De Blasi Irfan Qureshi Kirsi Kinnunen Marina Papoutsi Richard Joules Robin Wolz Multiple Systems Atrophy CNN Convolutional neural networks T1-Weighted T1W [ ](https://x.com/intent/tweet?url=https://ixico.com/news-and-resources/publications/validation-of-a-jacobian-ai-based-method-to-measure-cerebellar-volume-changes-in-multiple-system-atrophy/) [ ](https://bsky.app/intent/compose?text=https://ixico.com/news-and-resources/publications/validation-of-a-jacobian-ai-based-method-to-measure-cerebellar-volume-changes-in-multiple-system-atrophy/) [ ](https://www.facebook.com/sharer/sharer.php?u=https://ixico.com/news-and-resources/publications/validation-of-a-jacobian-ai-based-method-to-measure-cerebellar-volume-changes-in-multiple-system-atrophy/) [ ](https://www.linkedin.com/shareArticle?mini=true&url=https://ixico.com/news-and-resources/publications/validation-of-a-jacobian-ai-based-method-to-measure-cerebellar-volume-changes-in-multiple-system-atrophy/) [ Download ](/assets/downloads/Validation-of-a-Jacobian-AI-based-Method-to-Measure-Cerebellar-Volume-Changes-in-Multiple-System-Atrophy-ADPD_2023.pdf) ![Validation of a Jacobian AI based Method to Measure Cerebellar Volume Changes in Multiple System Atrophy ADPD 2023 v2](/assets/blog-images/Validation-of-a-Jacobian-AI-based-Method-to-Measure-Cerebellar-Volume-Changes-in-Multiple-System-Atrophy-ADPD_2023-v2__ScaleMaxWidthWzgwMF0_FillMaxWzgwMCw0NTBd_ExtRewriteWyJqcGciLCJ3ZWJwIl0.webp)The accurate, consistent, and scalable estimation of cerebellar atrophy would be highly beneficial for clinical trials in multiple system atrophy (MSA)1-3. This work performs validation of a fully automatic volume change workflow in MSA using Jacobian integration from non-linear warp-fields estimated with a convolutional neural network (CNN)-based 3D T1- weighted (T1W) image analysis workflow. The developed framework provides a fully automatic solution for estimating cerebellar volume change with increased sensitivity over comparable methods. Additionally, the framework is flexible and highly scalable, and as such has the potential to be advantageous for future clinical trials  Presented at ADPD 2023 in Gothenburg, Sweden [ Back to Scientific Publications ](/news-and-resources/publications/) ### Recents ![Evaluating the Impact of Scanner Harmonisation with ComBat on Longitudinal Brain Volume Measures in Huntington’s Disease](/assets/blog-images/EHDN-2026-Poster__ScaleMaxWidthWzgwMF0_FillMaxWzgwMCw0NTBd_ExtRewriteWyJwbmciLCJ3ZWJwIl0.webp) 29 Oct 26 publications [Evaluating the Impact of Scanner Harmonisation with ComBat on Longitudinal Brain Volume Measures in Huntington’s Disease](/news-and-resources/publications/evaluating-the-impact-of-scanner-harmonisation-in-huntingtons-disease/) [Neuromelanin-Sensitive MRI of the Substantia Nigra: Comparing TSE and MT-GRE Contrast](/news-and-resources/publications/contrast-ratio-assessment-of-the-substantia-nigra-in-neuromelanin-sensitive-mri/) [Improving Neuromelanin-sensitive MRI measurement ](/news-and-resources/publications/improving-neuromelanin-sensitive-mri-measurement/) [Further validation of IXI technology platform automation capabilities](/news-and-resources/publications/further-validation-of-ixi-technology-platform-automation-capabilities/) [Interchangeability of blood-based biomarkers and PET to identify Alzheimer's disease pathology](/news-and-resources/publications/interchangeability-of-blood-based-biomarkers-and-pet-to-identify-alzheimers-disease-pathology/) ### Library [November 2026](/news-and-resources/publications/archive/2026/11/) [October 2026](/news-and-resources/publications/archive/2026/10/) [September 2026](/news-and-resources/publications/archive/2026/09/) [July 2026](/news-and-resources/publications/archive/2026/07/) [June 2026](/news-and-resources/publications/archive/2026/06/) [May 2026](/news-and-resources/publications/archive/2026/05/) [April 2026](/news-and-resources/publications/archive/2026/04/) [March 2026](/news-and-resources/publications/archive/2026/03/) [February 2026](/news-and-resources/publications/archive/2026/02/) [January 2026](/news-and-resources/publications/archive/2026/01/) [2025](/news-and-resources/publications/archive/2025/) [2024](/news-and-resources/publications/archive/2024/) [2023](/news-and-resources/publications/archive/2023/) [2022](/news-and-resources/publications/archive/2022/) [2021](/news-and-resources/publications/archive/2021/) [2020](/news-and-resources/publications/archive/2020/) [2019](/news-and-resources/publications/archive/2019/)