# Erosion of The Supratentorial White Matter Reference for Increased Power in Longitudinal Amyloid PET 15 Aug 24 publications # Erosion of The Supratentorial White Matter Reference for Increased Power in Longitudinal Amyloid PET Colm J McGinnity Luis Peraza Richard B Joules Richard G Parker Robin Wolz [ ](https://x.com/intent/tweet?url=https://ixico.com/news-and-resources/publications/erosion-of-the-supratentorial-white-matter-reference-for-increased-power-in-longitudinal-amyloid-pet/) [ ](https://bsky.app/intent/compose?text=https://ixico.com/news-and-resources/publications/erosion-of-the-supratentorial-white-matter-reference-for-increased-power-in-longitudinal-amyloid-pet/) [ ](https://www.facebook.com/sharer/sharer.php?u=https://ixico.com/news-and-resources/publications/erosion-of-the-supratentorial-white-matter-reference-for-increased-power-in-longitudinal-amyloid-pet/) [ ](https://www.linkedin.com/shareArticle?mini=true&url=https://ixico.com/news-and-resources/publications/erosion-of-the-supratentorial-white-matter-reference-for-increased-power-in-longitudinal-amyloid-pet/) [ Download ](/assets/downloads/Erosion-of-The-Supratentorial-White-Matter-Reference-for-Increased-Power-in-Longitudinal-Amyloid-PET-AAIC-2024.pdf) ![Erosion of The Supratentorial White Matter Reference for Increased Power in Longitudinal Amyloid PET AAIC 2024](/assets/blog-images/Erosion-of-The-Supratentorial-White-Matter-Reference-for-Increased-Power-in-Longitudinal-Amyloid-PET-AAIC-2024__ScaleMaxWidthWzgwMF0_FillMaxWzgwMCw0NTBd_ExtRewriteWyJwbmciLCJ3ZWJwIl0.webp)The use of the supratentorial white matter as a reference region, alone 1 7 or in composite 3 can facilitate the detection of subtle changes in amyloid plaque burden Investigators often erode or otherwise restrict the sWM labels to reduce the influence of signal “spill in” from grey matter 2 4 8 but the optimal extent of erosion is unclear, and evaluations for 18 F radiotracers other than 18 florbetapir are scarce 8 The aim is to determine the optimal extent of erosion of the supratentorial white matter for use in a composite reference region, in longitudinal amyloid PET **Method** We evaluated the sensitivity of the eroded sWM using paired longitudinal amyloid PET and MR images acquired from participants who were cognitively normal or who had mild cognitive impairment , Alzheimer’s disease or subjective memory complaints at baseline. IXICO’s multi region LEAP pipeline was used to automatically segment the contemporaneous T 1 w MRIs into 143 regions with high accuracy.  We used our in-house PET analysis pipeline to process baseline and follow-up PET scans for each participant, including frame-to-frame realignment, co-registration, erosion of the sWM, quality control, and calculation of standardized uptake value ratios (SUVr) **Results** Outcome measures are reported as mean standard deviation over 10,000 samples (generated via bootstrapping with replacement). *Presented at AAIC 2024* [ Back to Scientific Publications ](/news-and-resources/publications/) ### Recents ![Evaluating the Impact of Scanner Harmonisation with ComBat on Longitudinal Brain Volume Measures in Huntington’s Disease](/assets/blog-images/EHDN-2026-Poster__ScaleMaxWidthWzgwMF0_FillMaxWzgwMCw0NTBd_ExtRewriteWyJwbmciLCJ3ZWJwIl0.webp) 29 Oct 26 publications [Evaluating the Impact of Scanner Harmonisation with ComBat on Longitudinal Brain Volume Measures in Huntington’s Disease](/news-and-resources/publications/new-blog-evaluating-the-impact-of-scanner-harmonisation-with-combat-on-longitudinal-brain-volume-measures-in-huntingtons-disease-post/) [Neuromelanin-Sensitive MRI of the Substantia Nigra: Comparing TSE and MT-GRE Contrast](/news-and-resources/publications/contrast-ratio-assessment-of-the-substantia-nigra-in-neuromelanin-sensitive-mri/) [Improving Neuromelanin-sensitive MRI measurement ](/news-and-resources/publications/improving-neuromelanin-sensitive-mri-measurement/) [Further validation of IXI technology platform automation capabilities](/news-and-resources/publications/further-validation-of-ixi-technology-platform-automation-capabilities/) [Interchangeability of blood-based biomarkers and PET to identify Alzheimer's disease pathology](/news-and-resources/publications/interchangeability-of-blood-based-biomarkers-and-pet-to-identify-alzheimers-disease-pathology/) ### Library [November 2026](/news-and-resources/publications/archive/2026/11/) [October 2026](/news-and-resources/publications/archive/2026/10/) [September 2026](/news-and-resources/publications/archive/2026/09/) [July 2026](/news-and-resources/publications/archive/2026/07/) [June 2026](/news-and-resources/publications/archive/2026/06/) [May 2026](/news-and-resources/publications/archive/2026/05/) [April 2026](/news-and-resources/publications/archive/2026/04/) [March 2026](/news-and-resources/publications/archive/2026/03/) [February 2026](/news-and-resources/publications/archive/2026/02/) [January 2026](/news-and-resources/publications/archive/2026/01/) [2025](/news-and-resources/publications/archive/2025/) [2024](/news-and-resources/publications/archive/2024/) [2023](/news-and-resources/publications/archive/2023/) [2022](/news-and-resources/publications/archive/2022/) [2021](/news-and-resources/publications/archive/2021/) [2020](/news-and-resources/publications/archive/2020/) [2019](/news-and-resources/publications/archive/2019/)