# Deep-learning methods for enrichment of Alzheimer’s Disease clinical trials using MRI and PET 3 Apr 23 publications # Deep-learning methods for enrichment of Alzheimer’s Disease clinical trials using MRI and PET Luis R Peraza Richard Joules Robin Wolz Alzheimers Disease MRI PET Deep Learning [ ](https://x.com/intent/tweet?url=https://ixico.com/news-and-resources/publications/deep-learning-methods-for-enrichment-of-alzheimers-disease-clinical-trials-using-mri-and-pet/) [ ](https://bsky.app/intent/compose?text=https://ixico.com/news-and-resources/publications/deep-learning-methods-for-enrichment-of-alzheimers-disease-clinical-trials-using-mri-and-pet/) [ ](https://www.facebook.com/sharer/sharer.php?u=https://ixico.com/news-and-resources/publications/deep-learning-methods-for-enrichment-of-alzheimers-disease-clinical-trials-using-mri-and-pet/) [ ](https://www.linkedin.com/shareArticle?mini=true&url=https://ixico.com/news-and-resources/publications/deep-learning-methods-for-enrichment-of-alzheimers-disease-clinical-trials-using-mri-and-pet/) [ Play Video ](https://youtube.com/watch?v=9VMb_DPBQ4E "Play Video") [ Download ](/assets/downloads/Deep-learning-Methods-For-Enrichment-Of-Alzheimers-Disease-Clinical-Trials-Using-MRI-And-PET-ADPD2023_poster.pdf) Drug development trials aimed to halt Alzheimer’s disease (AD) progression favour recruitment of participants at early stages, preferably before symptomatic onset. In this investigation, we developed a deep-learning framework to differentiate participants with accelerated cognitive decline from those that remain cognitively stable within 24 months. **Conclusions:** SUVR levels were associated with future cognitive decline in MCI but not in controls, while the CNN embeddings were able to identify both groups. Deep-learning algorithms offer a reliable framework to predict cognitive decline in MCI and control participants. Presented at ADPD 2023 in Gothenburg, Sweden [ Back to Scientific Publications ](/news-and-resources/publications/) ### Recents ![Evaluating the Impact of Scanner Harmonisation with ComBat on Longitudinal Brain Volume Measures in Huntington’s Disease](/assets/blog-images/EHDN-2026-Poster__ScaleMaxWidthWzgwMF0_FillMaxWzgwMCw0NTBd_ExtRewriteWyJwbmciLCJ3ZWJwIl0.webp) 29 Oct 26 publications [Evaluating the Impact of Scanner Harmonisation with ComBat on Longitudinal Brain Volume Measures in Huntington’s Disease](/news-and-resources/publications/evaluating-the-impact-of-scanner-harmonisation-in-huntingtons-disease/) [Neuromelanin-Sensitive MRI of the Substantia Nigra: Comparing TSE and MT-GRE Contrast](/news-and-resources/publications/contrast-ratio-assessment-of-the-substantia-nigra-in-neuromelanin-sensitive-mri/) [Improving Neuromelanin-sensitive MRI measurement ](/news-and-resources/publications/improving-neuromelanin-sensitive-mri-measurement/) [Further validation of IXI technology platform automation capabilities](/news-and-resources/publications/further-validation-of-ixi-technology-platform-automation-capabilities/) [Interchangeability of blood-based biomarkers and PET to identify Alzheimer's disease pathology](/news-and-resources/publications/interchangeability-of-blood-based-biomarkers-and-pet-to-identify-alzheimers-disease-pathology/) ### Library [November 2026](/news-and-resources/publications/archive/2026/11/) [October 2026](/news-and-resources/publications/archive/2026/10/) [September 2026](/news-and-resources/publications/archive/2026/09/) [July 2026](/news-and-resources/publications/archive/2026/07/) [June 2026](/news-and-resources/publications/archive/2026/06/) [May 2026](/news-and-resources/publications/archive/2026/05/) [April 2026](/news-and-resources/publications/archive/2026/04/) [March 2026](/news-and-resources/publications/archive/2026/03/) [February 2026](/news-and-resources/publications/archive/2026/02/) [January 2026](/news-and-resources/publications/archive/2026/01/) [2025](/news-and-resources/publications/archive/2025/) [2024](/news-and-resources/publications/archive/2024/) [2023](/news-and-resources/publications/archive/2023/) [2022](/news-and-resources/publications/archive/2022/) [2021](/news-and-resources/publications/archive/2021/) [2020](/news-and-resources/publications/archive/2020/) [2019](/news-and-resources/publications/archive/2019/)