# Volumetric change across the different Stages of the Huntington’s disease Integrated Staging System (HD-ISS) defined at baseline 2 Sep 24 publications # Volumetric change across the different Stages of the Huntington’s disease Integrated Staging System (HD-ISS) defined at baseline Cristina Sampaio Dorian Pustina Emily Gantman James Mills Jefrrey Long Marina Papoutsi Robin Wolz Huntingtons Disease HD-IH MRI [ ](https://x.com/intent/tweet?url=https://ixico.com/news-and-resources/publications/comparison-of-local-amyloid-pet-uptake-patterns-between-black-and-white-participants-in-the-gap-bio-hermes-study/) [ ](https://bsky.app/intent/compose?text=https://ixico.com/news-and-resources/publications/comparison-of-local-amyloid-pet-uptake-patterns-between-black-and-white-participants-in-the-gap-bio-hermes-study/) [ ](https://www.facebook.com/sharer/sharer.php?u=https://ixico.com/news-and-resources/publications/comparison-of-local-amyloid-pet-uptake-patterns-between-black-and-white-participants-in-the-gap-bio-hermes-study/) [ ](https://www.linkedin.com/shareArticle?mini=true&url=https://ixico.com/news-and-resources/publications/comparison-of-local-amyloid-pet-uptake-patterns-between-black-and-white-participants-in-the-gap-bio-hermes-study/) [ Download ](/assets/downloads/Volumetric-change-across-the-different-Stages-of-the-Huntingtons-disease-Integrated-Staging-System-HD-ISS-defined-at-baseline-HDTC24_poster_200824.pdf) ![Volumetric change across the different Stages of the Huntingtons disease Integrated Staging System HD ISS defined at baseline](/assets/blog-images/Volumetric-change-across-the-different-Stages-of-the-Huntingtons-disease-Integrated-Staging-System-HD-ISS-defined-at-baseline__ScaleMaxWidthWzgwMF0_FillMaxWzgwMCw0NTBd_ExtRewriteWyJwbmciLCJ3ZWJwIl0.webp)The HD Integrated Staging System enables classification of people with HD into four disease stages based on quantitative landmark assessments. Here we characterized volume change over time in the caudate nucleus, putamen, lateral ventricles, and whole-brain across participants starting in each of the different HD-ISS Stages at baseline and compared to healthy controls. We used a subset of data from TRACK-HD/ON and PREDICT-HD studies, which have been processed as part of the HD Imaging Harmonization (HD-IH) consortium. Volumetric analyses were performed using deep-learning and the generalized Boundary Shift Integra methods. **Method** We analysed data from 482 controls and 1,219 participants with HD across the four HD-ISS stages. Demographic details at baseline entry into the study are provided in the table below. Visits up to 6.5 years were included in the analyses. To enable differentiation between HD-ISS Stages 0 and 1 within the HD-IH consortium data, new cut-off values were calculated based on the control study participants for the HD-ISS Stage 1 landmarks, i.e. the putamen and caudate volume, adjusted by the affine scaling factor (ASF; Buckner et al. 2004), using the IXIQ.Ai methods. **Results** For all regions, there was a significant main effect of group, time, and group by time interaction (all p<0.001 Bonferroni corrected for four ROIs).The results from the post-hoc comparisons of the group by time interaction within the HD-ISS groups. Comparisons against the control group were all significant (all p < 0.01 corrected). P-values were Tukey-adjusted for a family of 5 estimates and then Bonferroni corrected for four ROIs. *Presented at EHDN 2024* [ Back to Scientific Publications ](/news-and-resources/publications/) ### Recents ![Evaluating the Impact of Scanner Harmonisation with ComBat on Longitudinal Brain Volume Measures in Huntington’s Disease](/assets/blog-images/EHDN-2026-Poster__ScaleMaxWidthWzgwMF0_FillMaxWzgwMCw0NTBd_ExtRewriteWyJwbmciLCJ3ZWJwIl0.webp) 29 Oct 26 publications [Evaluating the Impact of Scanner Harmonisation with ComBat on Longitudinal Brain Volume Measures in Huntington’s Disease](/news-and-resources/publications/new-blog-evaluating-the-impact-of-scanner-harmonisation-with-combat-on-longitudinal-brain-volume-measures-in-huntingtons-disease-post/) [Neuromelanin-Sensitive MRI of the Substantia Nigra: Comparing TSE and MT-GRE Contrast](/news-and-resources/publications/contrast-ratio-assessment-of-the-substantia-nigra-in-neuromelanin-sensitive-mri/) [Improving Neuromelanin-sensitive MRI measurement ](/news-and-resources/publications/improving-neuromelanin-sensitive-mri-measurement/) [Further validation of IXI technology platform automation capabilities](/news-and-resources/publications/further-validation-of-ixi-technology-platform-automation-capabilities/) [Interchangeability of blood-based biomarkers and PET to identify Alzheimer's disease pathology](/news-and-resources/publications/interchangeability-of-blood-based-biomarkers-and-pet-to-identify-alzheimers-disease-pathology/) ### Library [November 2026](/news-and-resources/publications/archive/2026/11/) [October 2026](/news-and-resources/publications/archive/2026/10/) [September 2026](/news-and-resources/publications/archive/2026/09/) [July 2026](/news-and-resources/publications/archive/2026/07/) [June 2026](/news-and-resources/publications/archive/2026/06/) [May 2026](/news-and-resources/publications/archive/2026/05/) [April 2026](/news-and-resources/publications/archive/2026/04/) [March 2026](/news-and-resources/publications/archive/2026/03/) [February 2026](/news-and-resources/publications/archive/2026/02/) [January 2026](/news-and-resources/publications/archive/2026/01/) [2025](/news-and-resources/publications/archive/2025/) [2024](/news-and-resources/publications/archive/2024/) [2023](/news-and-resources/publications/archive/2023/) [2022](/news-and-resources/publications/archive/2022/) [2021](/news-and-resources/publications/archive/2021/) [2020](/news-and-resources/publications/archive/2020/) [2019](/news-and-resources/publications/archive/2019/)