# Comparison of amyloid positivity and global cortical SUVR between black and white non-Hispanic participants in the GAP Bio-Hermes study 31 Jan 24 publications # Comparison of amyloid positivity and global cortical SUVR between black and white non-Hispanic participants in the GAP Bio-Hermes study Douglas Beauregard John Dwyer Lynne Hughes. Richard Manber Richard Mohs Robin Wolz Alzheimers Disease amyloid amyloid PET amyloid beta SUVR quantitative SUVR Bio-Hermes [ ](https://x.com/intent/tweet?url=https://ixico.com/news-and-resources/publications/comparison-of-amyloid-positivity-and-global-cortical-suvr-between-black-and-white-non-hispanic-participants-in-the-gap-bio-hermes-study/) [ ](https://bsky.app/intent/compose?text=https://ixico.com/news-and-resources/publications/comparison-of-amyloid-positivity-and-global-cortical-suvr-between-black-and-white-non-hispanic-participants-in-the-gap-bio-hermes-study/) [ ](https://www.facebook.com/sharer/sharer.php?u=https://ixico.com/news-and-resources/publications/comparison-of-amyloid-positivity-and-global-cortical-suvr-between-black-and-white-non-hispanic-participants-in-the-gap-bio-hermes-study/) [ ](https://www.linkedin.com/shareArticle?mini=true&url=https://ixico.com/news-and-resources/publications/comparison-of-amyloid-positivity-and-global-cortical-suvr-between-black-and-white-non-hispanic-participants-in-the-gap-bio-hermes-study/) [ Download ](/assets/downloads/Comparison-of-amyloid-positivity-and-global-cortical-SUVR-between-black-and-white-non-Hispanic-participants-in-the-GAP-Bio-Hermes-study-HAI-Jan-2024.pdf) ![Comparison of amyloid positivity and global cortical SUVR between black and white non Hispanic participants in the GAP Bio Hermes study 1](/assets/blog-images/Comparison-of-amyloid-positivity-and-global-cortical-SUVR-between-black-and-white-non-Hispanic-participants-in-the-GAP-Bio-Hermes-study-1__ScaleMaxWidthWzgwMF0_FillMaxWzgwMCw0NTBd_ExtRewriteWyJwbmciLCJ3ZWJwIl0.webp)**Summary:** This poster shows our further investigation on the amyloid PET differences between Black and White participants in the GAP Bio-Hermes study and to better understand the relationship between Aβ+ status from visual read and quantitative SUVR. **Method:** Visual read was performed centrally through the VisQ process in the MIM Software where visual inspection and and global cortical area SUVR is considered by a reader to perform classification into Aβ+ or Aβ-. We compare agreement between the visual reader and the previously proposed cut-off for Aβ+ from global cortical SUVR of 1.10 across the two racial groups. **Conclusion:** A substantially higher disagreement of SUVR cut-off with visual read in Aβ- Black participants compared to White participants was observed, suggesting a potential difference in amyloid uptake patterns between the two populations is driving differences in Aβ+ rates in the absence of differences in mean SUVR. In future work, regional SUVR analysis will be performed to further qualify these findings. 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