# AI-Driven Recruitment for Alzheimer’s Disease Clinical Trials: A Pilot Analysis on the A4 Study Dataset 4 Dec 25 publications # AI-Driven Recruitment for Alzheimer’s Disease Clinical Trials: A Pilot Analysis on the A4 Study Dataset Alzheimers Disease [ ](https://x.com/intent/tweet?url=https://ixico.com/news-and-resources/publications/ai-driven-recruitment-for-alzheimers-disease-clinical-trials-a-pilot-analysis-on-the-a4-study-dataset/) [ ](https://bsky.app/intent/compose?text=https://ixico.com/news-and-resources/publications/ai-driven-recruitment-for-alzheimers-disease-clinical-trials-a-pilot-analysis-on-the-a4-study-dataset/) [ ](https://www.facebook.com/sharer/sharer.php?u=https://ixico.com/news-and-resources/publications/ai-driven-recruitment-for-alzheimers-disease-clinical-trials-a-pilot-analysis-on-the-a4-study-dataset/) [ ](https://www.linkedin.com/shareArticle?mini=true&url=https://ixico.com/news-and-resources/publications/ai-driven-recruitment-for-alzheimers-disease-clinical-trials-a-pilot-analysis-on-the-a4-study-dataset/) [ Download ](/assets/downloads/AAIC2025_IXICO_SBRI-AI-Driven-Recruitment-for-Alzheimers-Disease-Clinical-Trials-A-Pilot-Analysis-on-the-A4-Study-Dataset.pdf) ![AI Driven Recruitment for Alzheimer’s Disease Clinical Trials A Pilot Analysis on the A4 Study Dataset N](/assets/blog-images/AI-Driven-Recruitment-for-Alzheimers-Disease-Clinical-Trials-A-Pilot-Analysis-on-the-A4-Study-Dataset-N__ScaleMaxWidthWzgwMF0_FillMaxWzgwMCw0NTBd_ExtRewriteWyJwbmciLCJ3ZWJwIl0.webp)Efficient recruitment in Alzheimer’s disease (AD) trials is challenging, and early use of sensitive biomarkers can reduce screen failures and costs. We evaluated an MRI-based machine learning model, previously trained to classify AD, FTD, normal controls, and other dementias, as a pre-screening tool using A4 Study data. The model successfully predicted higher amyloid burden in AD and OTH groups, supporting its utility for improving participant selection. While correlations with tau PET were absent—likely due to early disease stage—future work will refine thresholds and expand applicability. IXICO’s advanced imaging analytics and operational expertise enable precision recruitment, delivering measurable efficiency gains for clinical trials. [ Back to Scientific Publications ](/news-and-resources/publications/) ### Recents ![Evaluating the Impact of Scanner Harmonisation with ComBat on Longitudinal Brain Volume Measures in Huntington’s Disease](/assets/blog-images/EHDN-2026-Poster__ScaleMaxWidthWzgwMF0_FillMaxWzgwMCw0NTBd_ExtRewriteWyJwbmciLCJ3ZWJwIl0.webp) 29 Oct 26 publications [Evaluating the Impact of Scanner Harmonisation with ComBat on Longitudinal Brain Volume Measures in Huntington’s Disease](/news-and-resources/publications/new-blog-evaluating-the-impact-of-scanner-harmonisation-with-combat-on-longitudinal-brain-volume-measures-in-huntingtons-disease-post/) [Neuromelanin-Sensitive MRI of the Substantia Nigra: Comparing TSE and MT-GRE Contrast](/news-and-resources/publications/contrast-ratio-assessment-of-the-substantia-nigra-in-neuromelanin-sensitive-mri/) [Improving Neuromelanin-sensitive MRI measurement ](/news-and-resources/publications/improving-neuromelanin-sensitive-mri-measurement/) [Further validation of IXI technology platform automation capabilities](/news-and-resources/publications/further-validation-of-ixi-technology-platform-automation-capabilities/) [Interchangeability of blood-based biomarkers and PET to identify Alzheimer's disease pathology](/news-and-resources/publications/interchangeability-of-blood-based-biomarkers-and-pet-to-identify-alzheimers-disease-pathology/) ### Library [November 2026](/news-and-resources/publications/archive/2026/11/) [October 2026](/news-and-resources/publications/archive/2026/10/) [September 2026](/news-and-resources/publications/archive/2026/09/) [July 2026](/news-and-resources/publications/archive/2026/07/) [June 2026](/news-and-resources/publications/archive/2026/06/) [May 2026](/news-and-resources/publications/archive/2026/05/) [April 2026](/news-and-resources/publications/archive/2026/04/) [March 2026](/news-and-resources/publications/archive/2026/03/) [February 2026](/news-and-resources/publications/archive/2026/02/) [January 2026](/news-and-resources/publications/archive/2026/01/) [2025](/news-and-resources/publications/archive/2025/) [2024](/news-and-resources/publications/archive/2024/) [2023](/news-and-resources/publications/archive/2023/) [2022](/news-and-resources/publications/archive/2022/) [2021](/news-and-resources/publications/archive/2021/) [2020](/news-and-resources/publications/archive/2020/) [2019](/news-and-resources/publications/archive/2019/)