# A convolutional neural network-based framework for imaging biomarkers in MS - white matter hyperintensity & brain region volumes 24 Oct 23 publications # A convolutional neural network-based framework for imaging biomarkers in MS - white matter hyperintensity & brain region volumes Kirsi Kinnunen Convolutional neural networks white matter hypersensitivity ECTRIMS Multiple Sclerosis [ ](https://x.com/intent/tweet?url=https://ixico.com/news-and-resources/publications/a-convolutional-neural-network-based-framework-for-imaging-biomarkers-in-ms-white-matter-hyperintensity-and-brain-region-volumes-ectrims-2023/) [ ](https://bsky.app/intent/compose?text=https://ixico.com/news-and-resources/publications/a-convolutional-neural-network-based-framework-for-imaging-biomarkers-in-ms-white-matter-hyperintensity-and-brain-region-volumes-ectrims-2023/) [ ](https://www.facebook.com/sharer/sharer.php?u=https://ixico.com/news-and-resources/publications/a-convolutional-neural-network-based-framework-for-imaging-biomarkers-in-ms-white-matter-hyperintensity-and-brain-region-volumes-ectrims-2023/) [ ](https://www.linkedin.com/shareArticle?mini=true&url=https://ixico.com/news-and-resources/publications/a-convolutional-neural-network-based-framework-for-imaging-biomarkers-in-ms-white-matter-hyperintensity-and-brain-region-volumes-ectrims-2023/) [ Download ](/assets/downloads/A-convolutional-neural-network-based-framework-for-imaging-biomarkers-in-MS-white-matter-hyperintensity-brain-region-volumes-ECTRIMS-2023.pdf) ![A convolutional neural network based framework for imaging biomarkers in multiple sclerosis white matter hyperintensity and brain region volumes v2](/assets/blog-images/A-convolutional-neural-network-based-framework-for-imaging-biomarkers-in-multiple-sclerosis-white-matter-hyperintensity-and-brain-region-volumes-v2__ScaleMaxWidthWzgwMF0_FillMaxWzgwMCw0NTBd_ExtRewriteWyJqcGciLCJ3ZWJwIl0.webp)**Summary:** We developed and validated scalable and robust methods for automated volumetric analysis of brain white matter hyperintensities (T2 lesions) and regions of interest in multiple sclerosis. **Method:** We trained Convolutional Neural Networks (CNNs) to segment white matter hyperintensities (WMH) from 3D FLAIR scans and various brain regions from 3D T1W scans, including the thalamus and whole brain. We additionally measured whole-brain volume changes using Jacobian integration. We validated these methods on publicly available and internal datasets, using a consensus WMH segmentation as the ground truth for WMH and semi-automated segmentations as ground truths for brain regions. We assessed accuracy/robustness and test-retest performance. **Conclusion:** Our study demonstrated the accuracy of our WMH workflow; it outperformed other automated methods in terms of overlap and volume correlation with the ground truth. Furthermore, our brain region workflow provided high-quality and reliable results for the thalamus and whole-brain regions. The IXIQ.Ai framework offers a scalable and robust solution for the automated volumetric analysis of brain white matter hyperintensities and regions of interest in multiple sclerosis studies. This was presented at ECTRIMS-ACTRIMS 2023 (MSMilan2023) [ Back to Scientific Publications ](/news-and-resources/publications/) ### Recents ![Evaluating the Impact of Scanner Harmonisation with ComBat on Longitudinal Brain Volume Measures in Huntington’s Disease](/assets/blog-images/EHDN-2026-Poster__ScaleMaxWidthWzgwMF0_FillMaxWzgwMCw0NTBd_ExtRewriteWyJwbmciLCJ3ZWJwIl0.webp) 29 Oct 26 publications [Evaluating the Impact of Scanner Harmonisation with ComBat on Longitudinal Brain Volume Measures in Huntington’s Disease](/news-and-resources/publications/evaluating-the-impact-of-scanner-harmonisation-in-huntingtons-disease/) [Neuromelanin-Sensitive MRI of the Substantia Nigra: Comparing TSE and MT-GRE Contrast](/news-and-resources/publications/contrast-ratio-assessment-of-the-substantia-nigra-in-neuromelanin-sensitive-mri/) [Improving Neuromelanin-sensitive MRI measurement ](/news-and-resources/publications/improving-neuromelanin-sensitive-mri-measurement/) [Further validation of IXI technology platform automation capabilities](/news-and-resources/publications/further-validation-of-ixi-technology-platform-automation-capabilities/) [Interchangeability of blood-based biomarkers and PET to identify Alzheimer's disease pathology](/news-and-resources/publications/interchangeability-of-blood-based-biomarkers-and-pet-to-identify-alzheimers-disease-pathology/) ### Library [November 2026](/news-and-resources/publications/archive/2026/11/) [October 2026](/news-and-resources/publications/archive/2026/10/) [September 2026](/news-and-resources/publications/archive/2026/09/) [July 2026](/news-and-resources/publications/archive/2026/07/) [June 2026](/news-and-resources/publications/archive/2026/06/) [May 2026](/news-and-resources/publications/archive/2026/05/) [April 2026](/news-and-resources/publications/archive/2026/04/) [March 2026](/news-and-resources/publications/archive/2026/03/) [February 2026](/news-and-resources/publications/archive/2026/02/) [January 2026](/news-and-resources/publications/archive/2026/01/) [2025](/news-and-resources/publications/archive/2025/) [2024](/news-and-resources/publications/archive/2024/) [2023](/news-and-resources/publications/archive/2023/) [2022](/news-and-resources/publications/archive/2022/) [2021](/news-and-resources/publications/archive/2021/) [2020](/news-and-resources/publications/archive/2020/) [2019](/news-and-resources/publications/archive/2019/)