ECTRIMS 2016 Poster - Creating a consensus evaluation and expert opinion reporting platform for brain MRI in MS patients with increased risk of PML

Frederik Barkhof 1, 10 , Sara Llufriu 2, Àlex Rovira 3, Achim Gass 4, Claudio Gasperini 5, Hagen Kitzler 6, Jérôme Hodel 7, Jeremy Chataway 8, Tjalf Ziemssen 6, Mike Wattjes 1, Joep Killestein 1, Patrick Vermersch 7, John Hall 9, Sylke Grootonk 9, Natalie Royle 9, Derek Hill 9, Tarek Yousry 10

1. Department of Radiology & Nuclear Medicine, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands 2. Center for Neuroimmunology, Hospital Clinic Barcelona and IDIBAPS, Barcelona, Spain 3. Section of Neuroradiology, Department of Radiology, Vall d'Hebron University Hospital, Vall d'Hebron Research Institute, Autonomous University of Barcelona, Barcelona, Spain 4. Department of Neurology, Universitätsmedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. 5. Neurology Division, San Camillo Hospital, Rome, Italy. 6. Department of Neuroadiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, 01307 Dresden, Germany. 7. Departments of Neuroradiology, Hôpitaux Universitaires Henri Mondor, Créteil, France. 8. Univ. Lille, CHU Lille, LIRIC - INSERM U995, FHU Imminent, Lille, France. 9. Queen Square MS Centre, Department of Neuroinflammation, Institute of Neurology, University College London, London, WC1N 3BG, UK. 10. IXICO plc, 4th Floor Griffin Court, 15 Long Lane, EC1A 9PN, London, UK. 11. Queen Square MS Centre NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology; National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre; Brain Repair and Rehabilitation, UCL Institute of Neurology; Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, UK.


This poster was presented at the 2016 European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) conference by Natalie Royle on 16 September 2016. To see the abstract CLICK HERE.

Introduction and purpose: 

  • Progressive Multifocal Leukoencephalopathy (PML) is a potentially fatal complication of Multiple Sclerosis (MS) immunotherapeutics and a challenge for modern treatment strategies.

  • MRI is a very sensitive imaging technology for identification of PML and can detect asymptomatic occurrences. However lesion differentiation is challenging and requires dedicated neuroradiology expertise, rare outside of specialist centres.

  • The unstructured transfer of MR scans and other clinical information to specialist centres for 2nd opinion hampers effective communication between neurologists and radiologists and may compromise patient confidentiality.

  • A beta version of a platform (Assessa® PML) has been developed by IXICO in collaboration with subject matter experts, and is now being piloted

  • Assessa® PML provides a scalable expert reading service for rapid and reliable access to second opinion neuroradiology expertise in the setting of PML suspicion (see Figure 2 in full poster download).

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