ECTRIMS 2016 Abstract - Creating a consensus evaluation and expert opinion reporting platform for brain MRI in Multiple Sclerosis with higher increased risk of PML


Frederik Barkhof 1, 10 , Sara Llufriu 2, Àlex Rovira 3, Achim Gass 4, Claudio Gasperini 5, Hagen Kitzler 6, Jérôme Hodel 7, Jeremy Chataway 8, Tjalf Ziemssen 6, Mike Wattjes 1, Joep Killestein 1, Patrick Vermersch 7, John Hall 9, Sylke Grootonk 9, Natalie Royle 9, Derek Hill 9, Tarek Yousry 10

1. Department of Radiology & Nuclear Medicine, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands 2. Center for Neuroimmunology, Hospital Clinic Barcelona and IDIBAPS, Barcelona, Spain 3. Section of Neuroradiology, Department of Radiology, Vall d'Hebron University Hospital, Vall d'Hebron Research Institute, Autonomous University of Barcelona, Barcelona, Spain 4. Department of Neurology, Universitätsmedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. 5. Neurology Division, San Camillo Hospital, Rome, Italy. 6. Department of Neuroadiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, 01307 Dresden, Germany. 7. Departments of Neuroradiology, Hôpitaux Universitaires Henri Mondor, Créteil, France. 8. Univ. Lille, CHU Lille, LIRIC - INSERM U995, FHU Imminent, Lille, France. 9. Queen Square MS Centre, Department of Neuroinflammation, Institute of Neurology, University College London, London, WC1N 3BG, UK. 10. IXICO plc, 4th Floor Griffin Court, 15 Long Lane, EC1A 9PN, London, UK. 11. Queen Square MS Centre NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology; National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre; Brain Repair and Rehabilitation, UCL Institute of Neurology; Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, UK.

This abstract was submitted to the 2016 European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) and was presented at the event by Natalie Royle on 16 September 2016. To see the poster presentation CLICK HERE.


Progressive Multifocal Leukoencephalopathy (PML) is a potentially fatal complication of MS immunotherapeutics and a challenge for modern treatment strategies. MRI is very sensitive to PML and can detect asymptomatic PML. However lesion dierentiation is challenging and requires dedicated neuroradiology expertise, scarce outside specialised centres. In addition, unstructured transfer of MR scans hampers patient's confidentiality and effective communication between neurologists and radiologists. A digital platform will be developed to provide a scalable expert opinion reading service for rapid, reliable access to 2nd opinion neuroradiology expertise to identify PML suspicion. It is being piloted in clinical centres in Europe. The authors held a structured workshop which formed a consensus position of the use of this digital platform in a clinical setting. 

Download full abstract here